Neber reaction

Neber reaction

Primary Reference
- Neber, P.W.; Burghard, A. Justus Liebigs Ann. Chem., 1932, 493, 281-294.
The Neber reaction generates aminoketones by treatment of
sulfonic esters of ketoximes with alkoxide. It proceeds via an azirine intermediate.
Recent Examples
- Verstappen,M.M.H.; Ariaans, G.J.A.; Zwanenburg, B.* J. Am. Chem. Soc., 1996, 118, 8491-8492.
This example generates the azirine intermediate rather than the aminoketone.

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